Perforant Path Fiber Loss Results in Mnemonic Discrimination Task Deficits in Young Rats
نویسندگان
چکیده
منابع مشابه
Effect of low frequency stimulation of perforant path on kindling acquisition and synaptic transmission in the dentate gyrus in rats
Introduction: Previous studies have been shown that low frequency stimulation (LFS) has an inhibitory effect on kindling acquisition. However, the mechanism of this effect has not been completely determined. In the present study, the effect of LFS of the perforant path on seizures induced by rapid perforant path kindling was investigated. Methods: Animals were kindled by electrical stimulatio...
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Introduction: Considering high prevalence of epileptic disease and considering that 40 percent of epileptic patients are resistant to drug therapy, it needs more researches to find new therapeutic ways. LFS is among the new methods for epilepsy treatments. One possible mechanism involved in the anticonvulsant effect of LFS is increased adenosine. Therefore, in this study the role of adenosin...
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Alzheimer's disease, which is defined pathologically by abundant amyloid plaques and neurofibrillary tangles concurrent with synaptic and neuronal loss, is the most common underlying cause of dementia in the elderly. Among the oldest-old, those aged 90 and older, other ageing-related brain pathologies are prevalent in addition to Alzheimer's disease, including cerebrovascular disease and hippoc...
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46 47 The epileptic hippocampus has an enhanced propensity for seizure generation, but how 48 spontaneous seizures start is poorly understood. Using whole-cell and field-potential recordings, 49 this study explored whether repetitive perforant-path stimulation at physiological frequencies 50 could induce epileptiform bursts in dentate gyrus minislices from rats with kainate-induced 51 epilepsy....
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ژورنال
عنوان ژورنال: Frontiers in Systems Neuroscience
سال: 2018
ISSN: 1662-5137
DOI: 10.3389/fnsys.2018.00061